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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
LRP6
All Species:
30
Human Site:
S1508
Identified Species:
60
UniProt:
O75581
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75581
NP_002327.2
1613
180443
S1508
E
F
G
Y
S
S
N
S
P
S
T
H
R
S
Y
Chimpanzee
Pan troglodytes
XP_001152103
1613
180424
S1508
E
F
G
Y
S
S
N
S
P
S
T
H
R
S
Y
Rhesus Macaque
Macaca mulatta
XP_001117791
1209
134638
S1105
M
I
P
D
D
Q
H
S
P
D
L
I
L
P
L
Dog
Lupus familis
XP_534886
1613
180464
S1508
E
F
G
Y
S
S
N
S
P
S
T
H
R
S
Y
Cat
Felis silvestris
Mouse
Mus musculus
O88572
1613
180236
S1508
E
F
G
Y
S
S
N
S
P
S
T
H
R
S
Y
Rat
Rattus norvegicus
Q9QYP1
1905
211861
S1801
K
E
G
G
P
D
H
S
Y
T
K
E
K
I
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508455
1480
165692
P1376
F
G
Y
S
S
N
S
P
S
T
H
R
S
Y
S
Chicken
Gallus gallus
XP_417286
1567
175502
S1463
E
F
G
Y
S
S
N
S
P
S
T
H
R
S
Y
Frog
Xenopus laevis
NP_001079233
1613
180585
S1508
E
F
G
Y
S
S
N
S
P
S
T
H
R
S
Y
Zebra Danio
Brachydanio rerio
NP_001128156
1620
180715
S1512
E
F
G
Y
S
S
N
S
P
S
T
H
R
S
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P98163
1984
219502
L1807
W
L
M
A
L
F
V
L
A
A
G
S
L
I
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202408
1322
148003
P1218
L
R
Y
I
P
P
P
P
T
P
C
S
T
D
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
28.8
99.1
N.A.
97.8
28.3
N.A.
86.7
86.4
85.1
81.3
N.A.
20.1
N.A.
N.A.
42.2
Protein Similarity:
100
100
43.4
99.8
N.A.
99.3
45
N.A.
89.8
92
92.8
90.4
N.A.
36.1
N.A.
N.A.
56.5
P-Site Identity:
100
100
13.3
100
N.A.
100
13.3
N.A.
6.6
100
100
100
N.A.
0
N.A.
N.A.
0
P-Site Similarity:
100
100
20
100
N.A.
100
40
N.A.
26.6
100
100
100
N.A.
6.6
N.A.
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
9
0
0
0
0
9
9
0
0
0
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% C
% Asp:
0
0
0
9
9
9
0
0
0
9
0
0
0
9
0
% D
% Glu:
59
9
0
0
0
0
0
0
0
0
0
9
0
0
0
% E
% Phe:
9
59
0
0
0
9
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
9
67
9
0
0
0
0
0
0
9
0
0
0
0
% G
% His:
0
0
0
0
0
0
17
0
0
0
9
59
0
0
0
% H
% Ile:
0
9
0
9
0
0
0
0
0
0
0
9
0
17
9
% I
% Lys:
9
0
0
0
0
0
0
0
0
0
9
0
9
0
9
% K
% Leu:
9
9
0
0
9
0
0
9
0
0
9
0
17
0
9
% L
% Met:
9
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
9
59
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
9
0
17
9
9
17
67
9
0
0
0
9
0
% P
% Gln:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
9
0
0
0
0
0
0
0
0
0
9
59
0
0
% R
% Ser:
0
0
0
9
67
59
9
75
9
59
0
17
9
59
9
% S
% Thr:
0
0
0
0
0
0
0
0
9
17
59
0
9
0
0
% T
% Val:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% V
% Trp:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
17
59
0
0
0
0
9
0
0
0
0
9
59
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _